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The nematode resistance gene Mi of tomato confers resistance against the potato aphid. Proceedings of the National Academy of Sciences of the United States of America 95, 9750-9754.
| Rossi M., Goggin, Fiona L., Milligan, Stephen B., Kaloshian, Isgouhi, Ullman, Diane E., Williamson, Valerie M. (1998).
| Resistance against the aphid Macrosiphum euphorbiae previously was observed in tomato and attributed to a novel gene, designated Meu-1, tightly linked to the nematode resistance gene, Mi. Recent cloning of Mi allowed us to determine whether Meu-1 and Mi are the same gene. We show that Mi is expressed in leaves, that aphid resistance is isolate-specific, and that susceptible tomato transformed with Mi is resistant to the same aphid isolates as the original resistant lines. We conclude that Mi and Meu-1 are the same gene and that Mi mediates resistance against both aphids and nematodes, organisms belonging to different phyla. Mi is the first example of a plant resistance gene active against two such distantly related organisms. Furthermore, it is the first isolate-specific insect resistance gene to be cloned and belongs to the nucleotide-binding, leucine-rich repeat family of resistance genes.
By isolating the Mi-gene, a nematode resistance gene from tomato, and transforming it into susceptible lines, it could be shown that this gene is identical to the Meu-1 gene, which confers isolate-specific aphid resistance. Mi is the first example of a plant resistance gene active against two such distantly related organisms and it is the first isolate-specific insect resistance gene to be cloned.
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